VIP (Vasoactive Intestinal Peptide)
CIRS / mold protocol staple.
- Sizes available
- 5mg · 10mg
- Lab certificate (COA)
- Supplier-published sample
· Research-grade only · Not for human consumption · 21+ ·
Vasoactive intestinal peptide. Sleep, mood, and gut inflammation (CIRS protocol).
Mechanism · 28-Aa neuropeptide. VPAC1/VPAC2 GPCR. Anti-inflammatory + neuroendocrine.
Best for. Not for.
Best for
- CIRS (Chronic Inflammatory Response Syndrome) and mold-illness protocols.
- Sleep, mood, or neuroendocrine support.
- Users open to an intranasal spray.
Not for
- Prone to hypotension (high-dose BP drop).
- Pregnancy or nursing.
- Active immune dysregulation.
- Not FDA approved. Used only within the Shoemaker CIRS protocol.
Mechanism, dose, ramp, risk.
- Mechanism
- Vasoactive intestinal peptide. Anti-inflammatory + neuroendocrine modulation.Source · PEPVERA editorial
- Target dose
- 50 mcg, intranasal.Source · PEPVERA editorial
- Ramp
- 12 weeks.Source · PEPVERA editorial
- Risks
- Hypotension at high doses.Source · PEPVERA editorial
Compared to its siblings.
VIP (Vasoactive Intestinal Peptide)
Vasoactive intestinal peptide. Sleep, mood, and gut inflammation (CIRS protocol).
Pros
- · CIRS-protocol specificity absent in oxytocin and DSIP.
- · Broader neuroendocrine reach than DSIP's sleep-only target.
Cons
- · Less suited to mood and social applications than oxytocin.
- · Not sleep-targeted like DSIP.
Oxytocin
Bonding and mood neuropeptide. Intranasal.
Pros
- · Mood and social use.
Cons
- · Not specific to CIRS.
See Oxytocin →
DSIP
Sleep-specific peptide.
Pros
- · Sleep targeted.
Cons
- · No role in CIRS protocols.
See DSIP →
COA per supplier
Published, in-house, or shipment-time
Each supplier declares its own HPLC floor and COA policy. The per-supplier verifier appears on the certificate page; refund and shipping terms vary by supplier and are shown on the supplier listing.
Compare 4 suppliers
| Supplier | Price | COA | Ships | |
|---|---|---|---|---|
| Pure Peptide UKUK | $40$8.00/mg · 5mg | In-house COA | 4 days | Out of stock |
| Ameano PeptidesUS | $58$5.80/mg · 10mg | Sample COA published | 2 days | |
| PeptiraUS | $89$17.80/mg · 5mg | COA with shipment | 3 days | Out of stock |
| Ascension PeptidesUS | $94$9.40/mg · 10mg | Sample COA published | 3 days |
Direct from foundry. Slower than domestic resellers; consistency is the trade. Insulated packaging, tracked from departure to doorstep. Replacement issued on damage.
Week 1
50 mcg, intranasal.
Begin near site
Week 2–4
50 mcg, intranasal.
Daily, rotate
Week 5–6
50 mcg, intranasal.
Taper option
Week 7+
Maintenance
As needed
Draw 4 units.
0.2 mg = 0.04 mL at 5.00 mg/mL. 50.0 doses per vial.
repair · VIII · Ameano Peptides
VIP (Vasoactive Intestinal Peptide) · 10mg