Spermidine
ETERNAL · VII

Spermidine

Autophagy enhancer.

From / per milligram
$8$/mg · 1MG
Sizes available
Lab certificate (COA)
Arrives with shipment
View test certificate →

· Research-grade only · Not for human consumption · 21+ ·

What is it

Autophagy inducer. Longevity use. Dietary polyamine.

Mechanism · Polyamine. TFEB autophagy activator. Diet-derived (wheat germ / cheese).

Who

Best for. Not for.

Best for

  • Users with autophagy or cellular-cleanup goals
  • Diet-derived natural longevity intervention users prioritizing
  • Cognitive aging research participant (SmartAge Phase 2)
  • Oral capsule users on

Not for

  • Active malignancy, pregnancy, or nursing
  • Polyamine metabolism disorder
  • Acute infection (autophagy may be affected)
What it does

Mechanism, dose, ramp, risk.

Mechanism
Polyamine. Induces autophagy and mitophagy.Source · PEPVERA editorial
Target dose
1-3 mg / day, oral.Source · PEPVERA editorial
Ramp
Daily.Source · PEPVERA editorial
Risks
Few reports.Source · PEPVERA editorial
Alternatives

Compared to its siblings.

★ Currently viewing

Spermidine

Autophagy inducer. Longevity use. Dietary polyamine.

Pros

  • · Pre-clinical-only status avoided, with SmartAge Phase 2 cognitive trial running.

Cons

  • · No Sinclair Harvard pedigree behind it, unlike NAD.

NAD+

Sirtuin cofactor. Different longevity pathway.

Pros

  • · Sinclair Harvard research

Cons

  • · Different mechanism

See NAD+

MOTS-c

Mitochondrial peptide. Exercise mimetic.

Pros

  • · Targeted mitochondrial

Cons

  • · Pre-clinical

See MOTS-c

How we verify

COA per supplier

Published, in-house, or shipment-time

Each supplier declares its own HPLC floor and COA policy. The per-supplier verifier appears on the certificate page; refund and shipping terms vary by supplier and are shown on the supplier listing.

Suppliers

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❄ COLD-CHAIN · 5–9 DAYS

Direct from foundry. Slower than domestic resellers; consistency is the trade. Insulated packaging, tracked from departure to doorstep. Replacement issued on damage.

Dosing protocol

Week 1–2

1-3 mg / day, oral.

Initiation

Week 3–4

1-3 mg / day, oral.

Signal emerges

Week 5–8

1-3 mg / day, oral.

Hold

Week 9–12

Cycle review

Assess

Reconstitution

Draw 20 units.

0.1 mg = 0.20 mL at 0.50 mg/mL. 10.0 doses per vial.

eternal · VII

Spermidine · 1mg