
Spermidine
Autophagy enhancer.
- Sizes available
- —
- Lab certificate (COA)
- Arrives with shipment
· Research-grade only · Not for human consumption · 21+ ·
Autophagy inducer. Longevity use. Dietary polyamine.
Mechanism · Polyamine. TFEB autophagy activator. Diet-derived (wheat germ / cheese).
Best for. Not for.
Best for
- Users with autophagy or cellular-cleanup goals
- Diet-derived natural longevity intervention users prioritizing
- Cognitive aging research participant (SmartAge Phase 2)
- Oral capsule users on
Not for
- Active malignancy, pregnancy, or nursing
- Polyamine metabolism disorder
- Acute infection (autophagy may be affected)
Mechanism, dose, ramp, risk.
- Mechanism
- Polyamine. Induces autophagy and mitophagy.Source · PEPVERA editorial
- Target dose
- 1-3 mg / day, oral.Source · PEPVERA editorial
- Ramp
- Daily.Source · PEPVERA editorial
- Risks
- Few reports.Source · PEPVERA editorial
Compared to its siblings.
Spermidine
Autophagy inducer. Longevity use. Dietary polyamine.
Pros
- · Pre-clinical-only status avoided, with SmartAge Phase 2 cognitive trial running.
Cons
- · No Sinclair Harvard pedigree behind it, unlike NAD.
NAD+
Sirtuin cofactor. Different longevity pathway.
Pros
- · Sinclair Harvard research
Cons
- · Different mechanism
See NAD+ →
MOTS-c
Mitochondrial peptide. Exercise mimetic.
Pros
- · Targeted mitochondrial
Cons
- · Pre-clinical
See MOTS-c →
COA per supplier
Published, in-house, or shipment-time
Each supplier declares its own HPLC floor and COA policy. The per-supplier verifier appears on the certificate page; refund and shipping terms vary by supplier and are shown on the supplier listing.
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Direct from foundry. Slower than domestic resellers; consistency is the trade. Insulated packaging, tracked from departure to doorstep. Replacement issued on damage.
Week 1–2
1-3 mg / day, oral.
Initiation
Week 3–4
1-3 mg / day, oral.
Signal emerges
Week 5–8
1-3 mg / day, oral.
Hold
Week 9–12
Cycle review
Assess
Draw 20 units.
0.1 mg = 0.20 mL at 0.50 mg/mL. 10.0 doses per vial.
eternal · VII
Spermidine · 1mg