Kisspeptin-10
GnRH releaser.
- Sizes available
- —
- Lab certificate (COA)
- Arrives with shipment
· Research-grade only · Not for human consumption · 21+ ·
HPG axis modulator. GnRH stimulation (LH/FSH).
Mechanism · Decapeptide from KISS1 gene. GnRH neuron stimulation. HPG restart.
Best for. Not for.
Best for
- HPG axis research. Hypothalamic level stimulation
- Hypothalamic amenorrhea / functional hypogonadism research
- Users curious about the difference between direct GnRH stimulation and upstream kisspeptin
Not for
- Self-administered TRT restart (clinical supervision required)
- Hormone-sensitive cancer history
- Pregnancy / unstable pituitary mass
- No FDA / EMA approval. Imperial College still Phase 2
Mechanism, dose, ramp, risk.
- Mechanism
- Stimulates endogenous LH/FSH via GnRH. Restores HPG axis.Source · PEPVERA editorial
- Target dose
- 100 mcg subq.Source · PEPVERA editorial
- Ramp
- Cycle protocols.Source · PEPVERA editorial
- Risks
- Limited human protocols.Source · PEPVERA editorial
Compared to its siblings.
Kisspeptin-10
HPG axis modulator. GnRH stimulation (LH/FSH).
Pros
- · Upstream hypothalamic-level stimulation, one step above gonadorelin's pituitary action.
- · Upstream physiologic action versus HCG's testicular-only level.
Cons
- · No FDA approval; gonadorelin has Factrel and Lutrelef labels.
- · Research-only Phase 2 versus HCG's FDA Pregnyl/Novarel and 50+ year record.
Gonadorelin
Direct GnRH (pituitary level). Kisspeptin downstream.
Pros
- · Factrel/Lutrelef FDA history
- · Pulsatile pump protocol validated
Cons
- · Kisspeptin sits upstream of pituitary-level GnRH, in the hypothalamus
See Gonadorelin →
HCG (Research Grade)
LH analogue (testicular level). Restart validated.
Pros
- · FDA approved (Pregnyl/Novarel)
- · TRT adjunct standard
Cons
- · Testicular level only; no upstream HPG-axis stimulation
See HCG (Research Grade) →
COA per supplier
Published, in-house, or shipment-time
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Direct from foundry. Slower than domestic resellers; consistency is the trade. Insulated packaging, tracked from departure to doorstep. Replacement issued on damage.
Week 1–2
100 mcg subq.
Initiation
Week 3–4
100 mcg subq.
Signal emerges
Week 5–8
100 mcg subq.
Hold
Week 9–12
Cycle review
Assess
Draw 20 units.
0.5 mg = 0.20 mL at 2.50 mg/mL. 10.0 doses per vial.
drive · IV
Kisspeptin-10 · 5mg